The artistic collections, constantly being expanded to include new objects associated with the various expressions of cultural and artistic life of Bielsko-Biała and the wider region, now comprise around six thousand exhibits. The time frame spans from the 7th century BCE up to the modern times of the 21st century. The oldest exhibit is a facial piece from the cover of an Ancient Egyptian mummy from the twenty-sixth dynasty. There is an interesting collection among the exhibits of Gothic sculpture and paintings which represent sacral art. Many of these are depictions of the Madonna, such as the Madonna with a bird, from the end of the 14th century, and the Madonna wearing a mantle, from the beginning of the 16th century. The church art includes a triptych made in Antwerp at the turn of the 16th century with a centrally carved scene of the birth of Jesus and an image of Archangel Michael painted with tempera on board from Marcin Czarny’s Cracow studio. Apart from themes of a religious nature, painting and sculpture exhibits from the 17th to 19th centuries include portraits, generic, historical, battle, mythological and landscape scenes painted by Polish and foreign artists such as G. Assereto, C. von Balas, J. Brandt, F. Denys, S. Duplessis, A. Flamm, H. Goovearts, J. Kossak, T. Lubieniecki, J. Matejko, K. Markó, P. Michałowski, H. Rodakowski, H. Siemiradzki, D. van der Smissen, F. Wouters and many others.

The most interesting collection comprises paintings, prints, pottery, earthenware, glassware, silverware, pewter objects and fabric handicrafts, furniture and all manner of bric-a-brac from between the 19th and first part of the 20th century, directly related to the period of dynamic development of a middle class in Bielsko and Biała. It includes local society and political elite portraits, painted by such artists as P.M. Bohúň, M. Strzegocki, E. Świerkiewicz and J. Stokłosiński. A separate collection presents Art Nouveau graphic prints created by the best European artists of the time, published by Jahresmappe der Gesellschaft für vervielfältigende Kunst in Vienna between 1898 and 1920. There is also a rich collection of modern art - paintings, sculptures, objects, drawings and graphic art from the 20th and early 21st centuries. These include the works of artists from within the Young Poland movement such as S. Czajkowski, S. Filipkiewicz, V. Hofman, A. Karpiński, J. Malczewski, A. Neumann, I. Pieńkowski, J. Stanisławski, W. Weiss, L. Wyczółkowski and others. There are paintings by those who made up the artistic community of Bielsko and Biała in the 1920s during the interwar period, e.g. A. Bunsch, J. Fałat, J. Glasner, R. Harlfinger, B.P. Oczko, V. Strauss, F. Zitzman), as well as by those creating their art in this region in the second half of the previous century. On display is artwork created by painters still connected with the area today, members of the ‘Beskid Group’ which include J. Bieniek, J. Grabowski, K. Kopczyński, M. Kwaśny, J. Zipser i Z. Zwolski; A. Biedrawa, E. Delekta, J. Hołard, M. Kliś, B. Krzysztof, T. Sztwiertnia, H. Gocyła-Kocyba, E. Bergel, T. Moskała, R. Gryt, T. Król, J. and K. Dadakowie, K.M. Bąk, and P. Warchoł.  Finally, the museum presents paintings and graphic art created by the prize-winners of the ‘Bielsko Autumn’ National Painting Biennial.

Testament to the rapid expansion of artisanal organisations in both towns is the collection of exhibits related to the guilds, mainly the cloth shearers, tailors, weavers, clothiers, butchers and shoemakers. These include pewter chalices, ewers, and tankards, silver and gold-plated guild shields, leather and metal shields as well as guild wooden coffers with intarsia and polychrome decorations, also wrought iron coffers with stone-crafted inserts (the old strongboxes and safes). Apart from guild-related objects, there are also dishes for everyday use, dinnerware and decorative objects made from pewter, alloys of various metals, glass and porcelain, all created between the 17th and 20th centuries.

The collection also boasts an interesting display of miniatures from the 18th and 19th centuries, painted on ivory, canvas and porcelain, and also in the form of ivory or wax reliefs. The display of militaria presents examples of cold weapons and firearms, hunting weapons and various accoutrements associated with weaponry between the 16th and 20th centuries. There are also examples of artistic blacksmithing, everyday and more outstanding fabric work.